PRMT6 is a protein arginine methyltransferase responsible for histone H3 arginine 2 (H3R2) methylation. PRMT6 negatively regulates DNA methylation and that PRMT6 upregulation contributes to global DNA hypomethylation in cancer. Mechanistically, PRMT6 overexpression impairs the chromatin association of UHRF1, resulting in passive DNA demethylation. Especially, PRMT6 plays an important...