LC-MB12 is a FGFR2 PROTAC Degrader for Gastric Cancer Research
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.…
GXF-111 is a BRD3 and BRD4-L PROTAC Degradation Molecule for Cancer Research
PROTACs are bi-functional molecules, capable of concurrently binding to target proteins of interest and the subunits of E3 ligases, such as Cereblon, VHL, and MDM2, among others. In short, Cooperative…
dBRD9 is a PROTAC and can Selective Degrades BRD9
BRD9 is a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex. Besides, BRD9 contains a bromodomain and is closely related to BRD7. Importantly, The BRD9 gene is frequently present…
YX-2-107, a PROTAC, is a Selective CDK6 Degrader
Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia) is a rare subtype of leukemia characterized by the abnormal formation of the Philadelphia chromosome, which occurs when pieces of chromosomes 9 and…
SIAIS100 is a Potent BCR-ABL PROTAC Degrader
Chronic myeloid leukemia (CML) is a kind of myeloproliferative neoplasms (MPN). It is characterized by the proliferation of a pluripotential stem cell that can differentiate along the granulocytic lineage. In…
SJ988497, a PROTAC JAK2 Degrader, used for Acute Lymphoblastic Leukemia Research
CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is relevant with a poor outcome in children and adults. CRLF2r-ALL accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL. Noticeably, the overexpression…
U7D-1 is a Selective USP7 PROTAC Degrader For Leukemia Research
Ubiquitin-specific proteinase 7 (USP7) is a kind of de ubiquitination enzyme (DUB), which can remove ubiquitin and protect substrate protein from degradation. Besides, the full activity of USP7 requires the…
ARV-471 is an Estrogen Receptor PROTAC Degrader for Breast Cancer
PROTAC is a heterobifunctional molecule containing two small molecule binding moieties. Specifically, PROTACs in cells seek and selectively bind to target proteins. PROTAC then recruits specific E3 ligases to the…
MS159 is a First-In-class NSD2 PROTAC degrader for Multiple Myeloma Research
Proteolytic targeting chimera (PROTAC) is a heterobifunctional small molecule, including two active domains, and a linker. Importantly, it can remove specific unwanted proteins. PROTAC is a technology based on the…
MS170 is a PROTAC AKT Degrader
The alternative name of serine/threonine kinase AKT is protein kinase B (PKB). Three closely related genes in humans: AKT1 (PKB-α), AKT2 (PKB-β), and AKT3 (PKB-γ) encode PKB. AKT is an…