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Reliable, unbiased and up to date information in cancer research

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Gastric Cancer

LC-MB12 is a FGFR2 PROTAC Degrader for Gastric Cancer Research

Louis Gilman September 14, 2023

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.…

Cancer

GXF-111 is a BRD3 and BRD4-L PROTAC Degradation Molecule for Cancer Research

Louis Gilman June 29, 2023

PROTACs are bi-functional molecules, capable of concurrently binding to target proteins of interest and the subunits of E3 ligases, such as Cereblon, VHL, and MDM2, among others. In short, Cooperative…

uncategorized

dBRD9 is a PROTAC and can Selective Degrades BRD9

Louis Gilman March 21, 2023

BRD9 is a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex. Besides, BRD9 contains a bromodomain and is closely related to BRD7. Importantly, The BRD9 gene is frequently present…

Cancer Leukemia Ph+ ALL

YX-2-107, a PROTAC, is a Selective CDK6 Degrader

Louis Gilman January 12, 2023

Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia) is a rare subtype of leukemia characterized by the abnormal formation of the Philadelphia chromosome, which occurs when pieces of chromosomes 9 and…

Chronic Myeloid Leukemia

SIAIS100 is a Potent BCR-ABL PROTAC Degrader

Louis Gilman January 10, 2023

Chronic myeloid leukemia (CML) is a kind of myeloproliferative neoplasms (MPN). It is characterized by the proliferation of a pluripotential stem cell that can differentiate along the granulocytic lineage. In…

Acute Lymphoblastic Leukemia

SJ988497, a PROTAC JAK2 Degrader, used for Acute Lymphoblastic Leukemia Research

Louis Gilman December 23, 2022

CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is relevant with a poor outcome in children and adults. CRLF2r-ALL accounts for more than half of Philadelphia chromosome-like (Ph-like) ALL. Noticeably, the overexpression…

Acute Lymphoblastic Leukemia Cancer Lymphoma

U7D-1 is a Selective USP7 PROTAC Degrader For Leukemia Research

Louis Gilman December 6, 2022

Ubiquitin-specific proteinase 7 (USP7) is a kind of de ubiquitination enzyme (DUB), which can remove ubiquitin and protect substrate protein from degradation. Besides, the full activity of USP7 requires the…

Breast Cancer Cancer ER+ Breast Cancer

ARV-471 is an Estrogen Receptor PROTAC Degrader for Breast Cancer

Louis Gilman September 3, 2022

PROTAC is a heterobifunctional molecule containing two small molecule binding moieties. Specifically, PROTACs in cells seek and selectively bind to target proteins. PROTAC then recruits specific E3 ligases to the…

Multiple Myeloma Myeloma

MS159 is a First-In-class NSD2 PROTAC degrader for Multiple Myeloma Research

Louis Gilman August 26, 2022

Proteolytic targeting chimera (PROTAC) is a heterobifunctional small molecule, including two active domains, and a linker. Importantly, it can remove specific unwanted proteins. PROTAC is a technology based on the…

Cancer

MS170 is a PROTAC AKT Degrader

Louis Gilman February 27, 2022

The alternative name of serine/threonine kinase AKT is protein kinase B (PKB). Three closely related genes in humans: AKT1 (PKB-α), AKT2 (PKB-β), and AKT3 (PKB-γ) encode PKB. AKT is an…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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