Pegdinetanib (BMS-844203) is a Selective VEGFR-2 Inhibitor
Pegdinetanib (BMS-844203), an anti-angiogenic therapeutic agent, exemplifies a new class of targeted biologics called Adnectins. Adnectins are genetically engineered variants of the tenth type III domain of human fibronectin. Firstly, Adnectins are small proteins and have a high affinity to antibodies. Secondly, they are not glycosylated and have no...
Coibamide A, an Cytotoxic Depsipeptide, Induces Autophagosome Accumulation
Autophagy is the key structure of macroautophagy. Macroautophagy is an intracellular degradation system of cytoplasmic contents. Meanwhile, autophagy is a new double-membrane vesicle formed during autophagy, which can phagocytose a variety of intracellular substances. It transports this autophagic material to the lysosome for subsequent degradation. The lysosomal hydrolase degrades...