Tag: Wnt

WAY 316606 is an Inhibitor of the Secreted Protein sFRP-1

Human sFRP-1 is a 35 kD protein consisting of 313 amino acids. It containa 2 distinct structural domains, a netrin domain, and a cysteine-rich domain (CRD). The later domain is homologous to the Fzd receptor. sFRP-1 is thought to interact with Wnt via the CRD domain in a competitive...

MSAB is a Selective Inhibitor of Wnt/β-Catenin Signaling

Wnt/β-catenin signaling regulates key cellular functions including proliferation, differentiation, migration, apoptosis, and stem cell renewal. The β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. In this study, researchers screen for small molecule compounds that act against Wnt/β-catenin...