WAY 316606 is an Inhibitor of the Secreted Protein sFRP-1
Human sFRP-1 is a 35 kD protein consisting of 313 amino acids. It containa 2 distinct structural domains, a netrin domain, and a cysteine-rich domain (CRD). The later domain is homologous to the Fzd receptor. sFRP-1 is thought to interact with Wnt via the CRD domain in a competitive...
MSAB is a Selective Inhibitor of Wnt/β-Catenin Signaling
Wnt/β-catenin signaling regulates key cellular functions including proliferation, differentiation, migration, apoptosis, and stem cell renewal. The β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. In this study, researchers screen for small molecule compounds that act against Wnt/β-catenin...
IWP-O1, a Highly Potent Porcupine Inhibitor, Functions by Preventing the Secretion of Wnt Proteins
Secreted Wnt proteins play essential roles in embryonic development and adult tissue homeostasis. And the acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. In previous studies, Lin You et al describe herein the development of a new...