TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP
Apoptosis inhibitor proteins (IAP) represent a group of caspases and negative regulators of cell death. Particularly, the IAP protein family prevents cell death by binding to and inhibiting active caspases and is negatively regulated by IAP-binding proteins. In addition to cell death, IAP also acts as an innate immune...
Embelin is a Nonpeptidic XIAP Inhibitor
Embelin is an inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It derives from the fruit of Embelia ribes. Embelin also possess therapeutic properties, such as anticancer, antioxidant, anti-inflammation, antidiabetes, and antihelminthic qualities. XIAP is the most potent member of the inhibitors of apoptosis proteins (IAP) gene family....
Birinapant (TL32711), a Bivalent Smac Mimetic, is an Antagonist for XIAP and cIAP1
XIAP is a protein that prevents apoptosis. XIAP is a member of apoptosis protein family (IAP) inhibitors. Specifically, IAP blocks cell death in vitro and in vivo by inhibiting different caspases. The caspase inhibitory activity of XIAP is negatively regulated by at least two XIAP interacting proteins XAF1 and...
APG-1387, a Bivalent SMAC Mimetic, Induces Proteasomal Degradation of IAPs
Apoptosis protein inhibitors (IAP) are a class of functional and structural proteins, which are endogenous inhibitors of apoptosis. Specifically, inappropriate mutation or regulation will usually lead to cancer or other effects on cells. They include the Bcl-2 family, viral inhibitor crmA, and IAP’s. Besides, the most characteristic of IAAP...