SM1-71 is a Multi-Targeted Kinase Inhibitor with Anti-Cancer Activity
In this article, we will introduce a potent TAK1 inhibitor, with a Ki of 160 nM. SM1-71 inhibits MEK1 activities with an IC50 of 142 nM. It also exhibits only weak activity against ERK2 with an IC50 of 1090 nM. Additionally, SM1-71 has an acrylamide warhead in the ortho-position. At the same time, it...
CH6953755 is an Orally Active and Selective YES1 Kinase Inhibitor
There are reports of YES1 participating in numerous signaling pathways. SRC is a nonreceptor protein tyrosine kinase and is encoded by a proto-oncogene. Besides, the nine members of the SRC family include YES1, SRC, FYN, LYN, and LCK, have various important cellular functions. Moreover, down-regulating YES1 by short hairpin...