Olutasidenib is a Mutant IDH1 Inhibitor for the Treatment of AML or MDS
Acute myeloid leukemia (AML) is a kind of cancer diseases, a cancer of the myeloid line of blood cells. AML seriously affects patients’ life as we previously mentioned in our…
Acute myeloid leukemia (AML) is a kind of cancer diseases, a cancer of the myeloid line of blood cells. AML seriously affects patients’ life as we previously mentioned in our…
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory subunit- a cyclin. CDKs play important roles in the control of cell division and modulate transcription in response…
Peripheral T-cell lymphomas (PTCL) accounted for about 5% of all non-Hodgkin’s lymphomas. Standard first line treatment is with combination chemotherapy but the majority of patients relapse. There is no standard…
G-quadruplexes are unique four-stranded structures formed by guanine-rich nucleic acid sequences. G-quadruplexes are widely distributed in many important regulatory regions in the human genome, notably in telomeres and promoters of…
Receptor interacting protein (RIP) kinases are a group of threonine/serine protein kinases. They have a relatively conserved kinase domain but distinct non-kinase regions. The RIP kinases contain seven members, all…
SUV39H2 (Suppressor of variegation 3-9 homolog 2), also known as KMT1B, is a member of the SUV39 subfamily of lysine methyltransferases (KMTs). SUV39H2 results in heterochromatin formation and transcriptional repression.…
Epigenetic alterations are a recognized hallmark of cancer cells, and several lines of evidence link aberrant EZH2 (Enhancer of Zeste Homolog 2) activity to tumor initiation and progression. EZH2 is…
Secreted Wnt proteins play essential roles in embryonic development and adult tissue homeostasis. And the acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic…
As we all know, cancer has become one of the most serious diseases in the world. There are more than 100 types of cancer. Such diseases severely affect patients’ life.…
Her3 (also known as ErbB3) is a member of the epidermal growth factor receptor (EGFR) tyrosine kinases, including Her1, Her2 and Her4. However, owing to receptor or ligand overexpression or…