PhiKan 083, a Potent p53 Mutant Stabilizer for Cancer Research
Tumor suppressor p53 is an important protein in cells. It regulates cell cycle, apoptosis and genomic stability. Most mutation of p53 is inactive in half of human cancers. Mutant p53…
Tumor suppressor p53 is an important protein in cells. It regulates cell cycle, apoptosis and genomic stability. Most mutation of p53 is inactive in half of human cancers. Mutant p53…
Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal cortex. ACC is highly aggressive with many patients presenting with metastases upon diagnosis. Therapeutic options for the treatment of ACC…
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Necroptosis plays an important role in many pathological processes such as ischemia-reperfusion injury and host defense…
Aberrations in post-translational modifications by ubiquitin or ubiquitin-like proteins (Ubl), such as the small ubiquitin-like modifiers (SUMO) relate to the pathogenesis of lifethreatening diseases, such as cancer, neurodegenerative disorders, and…
Cyclin G-associated kinase (GAK) is a 160 kDa serine/threonine kinase. Importantly, GAK features high homology outside its kinase domain with auxilin. GAK regulates receptor tyrosine kinases, such as the EGF…
The bromodomain-containing protein BRD9, a recently identified mSWI/SNF subunit, is a novel complex configuration distinct from BAF and PBAF. The mSWI/SNF (BAF) complex comprises at least 15 subunits of ~2…
Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases. They are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover. Elevated…
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. While the application of targeted tyrosine kinase inhibitors has revolutionized the treatment of gastrointestinal stromal tumors…
Estrogen receptor is a nuclear receptor activated by estrogen, existing inside cells. The receptor contains two types, ERα and ERβ. The former is always expressed in breast cancer, which…
Centrosome is an important organelle. It acts as the main microtubule organizing center (MTOC), regulates cell-cycle progression in mammalian cells. In normal cells, centrosome duplication occurs in the early phase…