A1874 is a Nultin-based BRD4-degrading PROTAC
In recent years, the studies associated with PROTAC have grown steadily. And Although the E3 ligase MDM2 is bound by the nutlin class of small-molecule ligands, there are few nutlin-based…
In recent years, the studies associated with PROTAC have grown steadily. And Although the E3 ligase MDM2 is bound by the nutlin class of small-molecule ligands, there are few nutlin-based…
To develop small molecules that modulate protein-protein interactions (PPIs) displays a significant therapeutic potential. However, rational design of small molecule enhancers of PPIs remains elusive. A study from Kyle R.…
Protein kinases inhibition is a common therapeutic strategy for many diseases, including cancers, inflammatory diseases, diabetes and neurodegenerative disorders. The Ser-/Thr-specific kinase Akt is also known as protein kinase B.…
Tumor suppressor p53 is an important protein in cells. It regulates cell cycle, apoptosis and genomic stability. Most mutation of p53 is inactive in half of human cancers. Mutant p53…
Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases. They are responsible for the degradation of most extracellular matrix proteins during organogenesis, growth and normal tissue turnover. Elevated…