Tag: Androgen Receptor

EPI-001 is a Selective Inhibitor of Androgen Receptor with Anti-tumor Activity

The androgen receptor (AR) is a type of nuclear receptor and a modular steroid hormone receptor transcription factor. Specifically, the androgen receptor is activated by binding any of the androgenic hormones then translocating into the nucleus. Besides, the main function of the androgen receptor is to regulate gene expression...

Y06137 is a Selective BET Inhibitor for Treatment of CRPC

Prostate cancer arises as an androgen driven disease. Therefore the mainstay of systemic therapy for patients with advanced disease is androgen deprivation therapy. Despite of significant responses, nearly all patients ultimately progress and castration resistance ensues. Castration resistant prostate cancer therefore represents a stage in the continuum of the...

A Novel Potent and Specific BET Inhibitor Y06036 For Prostate Cancer

Prostate cancer is the most common malignancy and the fifth leading cause of death from malignancy in men. Since androgen receptor (AR) signaling has a pivotal role in prostate cancer, androgen deprivation therapy (ADT) with surgical or chemical castration is the standard treatment with most patients going to remission....