The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…
Fms-related tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expresses on hematopoietic cells. However, FLT3 plays a critical role in both normal and malignant hematopoiesis. According to existing research…
Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of…
Onvansertib, a PLK1-specific ATP competitive inhibitor, blocks the phosphorylation of PLK1 substrates. Polo was first identified in Drosophila melanogaster. The family of polo-like serine/threonine kinases includes 5 members: PLK1, PLK2,…
Apoptosis is a cellular process critical to the normal development and homeostasis of multicellular organisms. Therefore, dysfunction of the apoptosis machinery has been linked to many human diseases. These diseases…
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more…
Hsp90 (heat shock protein 90) is a chaperone protein that helps other proteins fold correctly, stabilizes proteins against heat stress, and aids in protein degradation. Besides, it stabilizes many proteins…
Checkpoint kinase 1 (Chk1) is a conserved protein kinase that is critical to the Cell cycle checkpoint during DNA damage response (DDR). Specifically, CHK1 is the regulatory factor for G2/M…
MY-943 is a potent tubulin polymerization and LSD1 inhibitor with anticancer activity. Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of…
IGF2BP2, also known as IMP2, is a member of the insulin-like growth factor 2 messenger RNA-binding protein (IGF2BP) family that is highly conserved in vertebrates. Besides, it was first identified…