VU0359595 is a Selective PLD1 Inhibitor
Phospholipase is a member of a very complex group of enzymes that break down phospholipids into fatty acids and other compounds. Phospholipase D (PLD) is an enzyme of the phospholipase superfamily. There are two mammalian isoforms of PLD, coined PLD1 and PLD2, and despite conserved regulatory and catalytic domains....
BRD3731 is a Selective GSK3β Inhibitor
Glycogen synthase kinase 3 (GSK3) is a key regulatory kinase in the WNT pathway. GSK3 remains a therapeutic target of interest in many diseases. GSK3 represents an example of such an evolutionary selection system, resulting in two paralog genes, GSK3A on chromosome 19 and GSK3B on chromosome 3. The...