Tag: GTPase

ML-099 is a pan Ras-Related GTPases Activator

To date, we identified 167 small GTPases in humans which are key signal transducing enzymes. Small GTPases comprise five main families whose eponymous members are Ras, Rho, Rab, ADP-ribosylation factor (Arf) and Ran. Small GTPases link extracellular cues to the neuronal responses required for the construction of neuronal networks,...

CID-1067700 is a Ras GTPases pan-Inhibitor with High Efficacy Towards Rab7

Alteration of small GTPase functions is a hallmark of genetic and sporadic human diseases, making GTPase family members attractive though understudied targets. Specifically, the Ras superfamily of GTPases includes Arf, Rho, Ras and Rab GTPase subfamilies. Besides, they regulate a broad range of cellular processes ranging from membrane trafficking...