ENMD-1198, an Orally Active Tubulin-Binding Agent, Reduces HIF-1α and STAT3 Activity
Hepatocellular carcinoma (HCC) is the fifth most cancer worldwide, with a continuously increasing incidence. HCC represents a hyper vascularized tumor and its progression is closely related to angiogenesis. Hepatocellular carcinoma overexpresses the vascular endothelial growth factor (VEGF). The transcription factor HIF-1α also plays a central role in HCC progression...
CGS 15943 is an Orally Active Adenosine Receptor Antagonist
Hepatocellular carcinoma (HCC) is primary liver cancer and the third most common cause of cancer mortality worldwide. CGS 15943 blocks proliferation in hepatocellular carcinoma (HCC) and pancreatic cancer adenocarcinoma (PDAC) cell lines by inhibiting the PI3K/Akt pathway. Researchers test the adenosine A2 receptor antagonist CGS 15943 for cerebroprotective activity in...
KU-0060648 is a Dual PI3K and DNA-PK Inhibitor
DNA double-strand breaks (DSBs) are the principal cytotoxic lesions induced by topoisomerase II poisons. And DSB inhibitors are widely applied in the treatment of a variety of human solid malignancies and leukemia. Cells defective in DSB repair by virtue of the inactivation of a component of the NHEJ pathway...