Saracatinib (AZD0530) is a potent Src Family Inhibitor
Src is a prototypical non-receptor tyrosine kinase. It also includes c-Yes and Fyn. Src transduces signals that control processes involved in cell proliferation, adhesion, and motility. Clinical evidence supports a link between deregulation of Src activity and tumor progression and metastasis. Src over-expression and activation are associated with numerous...
ML339 is a Selective CXCR6 Antagonist
Prostate cancer is cancer that occurs in the prostate. Prostate cancer is the second-leading cause of cancer deaths for men. Especially, Prostate cancer is one of the most common types of cancer. The morbidity/mortality of prostate cancer has increased globally in recent years. The high mortality rate closely associates...
MPT0G211 is an Orally Active and Selective HDAC6 Inhibitor
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, accounting for more than 80% of dementia cases worldwide. AD leads to the progressive loss of mental capacity and behavior, with a functional decline in the ability to learn. HDAC6 belongs to the HDAC family, and its structure contains...
EW-7195 is a Specific ALK5 (TGFβR1) Inhibitor with Anti-Metastasis Activity
Breast cancer is the leading cause of cancer mortality among women in Korea, England, and the United States of America. Invasion and metastasis are the most lethal characteristics of breast cancer. TGF-β signaling maintains homeostasis and elicits tumor-suppressive responses such as growth inhibition and apoptosis in normal mammary epithelial...
ZINC69391 is a Specific Rac1 Inhibitor and Apoptosis Inducer
Rho-GTPases are molecular switches that cycle between an inactive GDP-bound form and an active GTP-bound form. Guanine nucleotide exchange factors (GEFs) catalyze nucleotide exchange and mediate activation in this cycle, While GTPase-activating proteins (GAPs) stimulate GTP hydrolysis and inactivate the GTPase. Only the active GTP-bound state binds to downstream...
CCT365623, an Orally Active LOX Inhibitor, Supresses EGFR (pY1068) and AKT Phosphorylation
Lysyl oxidase (LOX) is a copper and quinone-cofactor containing amine oxidase. It is an inactive pro-enzyme and can be cleaved to a mature active form by extracellular metalloproteases. LOX prompts the formation of covalent bonds in collagens and elastin. Thereby, it increases the stiffness of the ECM. Besides, many...
ZLDI-8, an ADAM-17 and Notch Inhibitor, Enhances Chemotherapeutic Effects
ADAM metallopeptidase domain 17 (ADAM17) is an enzyme that belongs to the ADAM protein family of metalloproteases. ADAM17 plays a prominent role in the Notch signaling pathway. In this study, researchers demonstrated the discovery of ZLDI-8. ZLDI-8 is a novel inhibitor for Notch activating/cleaving enzyme ADAM-17. In particular, ZLDI-8...