Tag: Mitophagy

ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor

Bcl-2 protein family is a key regulator of apoptosis and a marker of B-cell lymphoma. Importantly, apoptosis is an important physiological process of selective cell clearance, involving a variety of biological events. Particularly, the Bcl-2 family is the most characteristic protein family involved in regulating apoptotic cell death. It...

AUTAC4 is a Mitochondria-Targeting Autophagy-Targeting Chimera (AUTAC)

A novel chimeric molecule, namely autophagy-targeting chimera (AUTAC), is the first degrader using the autophagy mechanism. AUTAC consists of a guanine tag and a specific binder of an intracellular target of interest. In addition, AUTAC can penetrate cell membranes, and degrade fragmented mitochondria as well as proteins. Mitochondria not...