AUTAC4 is a Mitochondria-targeting Autophagy-targeting Chimera (AUTAC).
AUTAC4 is a Mitochondria-targeting Autophagy-targeting Chimera (AUTAC). Besides, AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy. Autophagy-targeting chimera (AUTAC) degrades target proteins via a lysosomal pathway rather than the common proteasome pathway. Besides, One end of AUTAC is a target protein-ligand, the other end is a...
ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor
Bcl-2 protein family is a key regulator of apoptosis and a marker of B-cell lymphoma. Importantly, apoptosis is an important physiological process of selective cell clearance, involving a variety of biological events. Particularly, the Bcl-2 family is the most characteristic protein family involved in regulating apoptotic cell death. It...
AUTAC4 is a Mitochondria-Targeting Autophagy-Targeting Chimera (AUTAC)
A novel chimeric molecule, namely autophagy-targeting chimera (AUTAC), is the first degrader using the autophagy mechanism. AUTAC consists of a guanine tag and a specific binder of an intracellular target of interest. In addition, AUTAC can penetrate cell membranes, and degrade fragmented mitochondria as well as proteins. Mitochondria not...