CC214-1 is a mTOR Inhibitor for Glioblastoma Research
mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. Then, mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation,…
SN32976 is a Selective Class I PI3K and mTOR Inhibitor for Cancer Research
The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates a number of crucial cellular processes, including growth, survival, angiogenesis, migration and metabolism. The PI3K family consists of four isoforms: Class I, Class…
Coibamide A, an Cytotoxic Depsipeptide, Induces Autophagosome Accumulation
Autophagy is the key structure of macroautophagy. Macroautophagy is an intracellular degradation system of cytoplasmic contents. Meanwhile, autophagy is a new double-membrane vesicle formed during autophagy, which can phagocytose a…
Vistusertib (AZD2014) is an ATP Competitive mTOR Inhibitor
mTOR is an atypical serine threonine kinase involved in regulating major cellular functions, such as nutrients sensing, growth, and proliferation. mTOR is part of the multiprotein complexes mTORC1 and mTORC2.…
Sapanisertib is an Orally Active and ATP-Dependent mTOR Inhibitor
Acute myelogenous leukemia (AML) is a heterogeneous disease. It often relapses after standard chemotherapy or proves refractory to available treatments. Therefore, It needs novel therapies for AML. In AML, many…
Everolimus (RAD001), a Rapamycin Derivative, is a Selective and Orally Active mTOR1 Inhibitor
mTOR is a member of the phosphatidylinositol 3-kinase related kinase family of protein kinases. Meanwhile, mTOR is linked to other proteins and serves as the core component of two different…
Rapamycin is a Specific mTOR Inhibitor
mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell…
PF-06843195 is a Selective PI3Kα Inhibitor
Phosphoinositide 3-kinases (PI3Ks) can catalyze the synthesis of the phosphatidylinositol (PI) second messengers, including PI(3)P (PIP), PI(3,4)P2 (PIP2), and PI(3,4,5)P3 (PIP3). The PI3K lipid kinase family contains three classes based…
RapaLink-1, a Third-Generation Bivalent mTOR Inhibitor, Combines Rapamycin with MLN0128
Glioblastoma (GBM), the most common primary brain tumor, represents one of the most aggressive cancers. The signaling from PI3K and AKT to mTOR is commonly dysregulated in GBM. But, blockade…
PI-103 is a Potent PI3K and mTOR Inhibitor
The phosphatidylinositide 3-kinase family possesses 15 members. those members consist of four distinct classes as a basis on their structure and biological properties. As we all know, this highly conserved…