Tag: mTOR

PI-103 is a Potent PI3K and mTOR Inhibitor

The phosphatidylinositide 3-kinase family possesses 15 members. those members consist of four distinct classes as a basis on their structure and biological properties. As we all know, this highly conserved family of enzymes involves various aspects of cellular homeostasis and exists a decline in a number of pathophysiologic conditions....

CC-223 is an Orally Bioavailable mTOR Kinase Inhibitor

mTOR is a serine/threonine kinase that regulates cell growth, metabolism, proliferation, and survival. mTORC1 is a master regulator of cell growth and metabolism. mTORC1 positively regulates cell growth and proliferation. mTORC2 regulates cytoskeletal organization. CC-223 is a potent mTOR kinase inhibitor with an IC50 of 0.016 μM. CC-223 is...

MRT67307 Blocks mTOR-Dependent Autophagy by Inhibiting ULK1 Kinase

Yesterday, I introduced a dual IKKε/TBK1 inhibitor MRT67307. Studies have showed that MRT67307 plays a significant role in innate immunology. Not only this, a study from Katy J. Petherick drew a conclusion that MRT67307 blocked mTOR-dependent autophagy by inhibiting ULK1 kinase. ULK1, is believed to be specific for autophagy....

BGT226 is a Dual PI3K/mTOR Inhibitor

The phosphoinositide 3-kinase (PI3K) pathway has key roles in regulating physiologic functions, including cellular proliferation, growth, metabolism, and survival. The PI3K pathway frequently activats in cancer cells, via several mechanisms, including mutation of PI3K signaling components and downstream effectors. One example is the aberrant expression of phosphoinositide 3-kinase (PI3K)/AKT/mTOR....