The protein tyrosine phosphatase SHP2 (also called SH-PTP2, Syp, PTP1D, and PT-P2C) is a ubiquitously expressed 68 kDa non-receptor PTP. In the inactive state, the SH2 domains of SHP2 auto-inhibit the catalytic PTP domain by binding intramolecularly to the defined acidic residues. Upon activation, several receptor tyrosine kinases, including MET,...