PRN1008 is a Reversible Covalent and Oral Active Inhibitor of Bruton’s Tyrosine Kinase (BTK)
Bruton’s tyrosine kinase (BTK) is a nonreceptor tyrosine kinase in human encoded by BTK gene. Besides, the kinase belongs to the TEC protein tyrosine kinase family of kinases. Additionally, this kind of tyrosine kinase plays a crucial role in B cell maturation as well as mast cell activation through...
Novel Greatwall Kinase Inhibitor GKI-1
Greatwall kinase (GWL) is a critical regulator of mitosis and meiosis. It regulates PP2A-B55 activity by phosphorylating two proteins, Arpp19 and ENSA. This phosphorylation turns these proteins into potent inhibitors of PP2A-B55, thereby promoting a correct timing and progression of mitosis. When over-expressed in breast cancer, GWL induces oncogenic...