CYD-4-61 is a Bax Activator Used for Breast Cancer Research
Bax is an apoptosis regulator, belonging to the Bcl-2-like protein family. It controls mitochondrial dysfunction and apoptosis. Bax can promote apoptosis by forming a heterodimer with Bcl-2 to become a lethal mitochondrial pore protein. Specifically, it can induce mitochondrial outer membrane permeability, release cytochrome c, and cause programmed death...
GNE-149 is an Orally Active Estrogen Receptor α Antagonist
Estrogen receptor α (ERα) and β (ERβ) is a nuclear transcription factors involved in regulating many complex human physiological processes. Moreover, these proteins play a role in the nucleus and regulate the transcription of specific target genes by binding with relevant DNA regulatory sequences. The interaction between ligands, receptors,...
EPI-001 is a Selective Inhibitor of Androgen Receptor with Anti-tumor Activity
The androgen receptor (AR) is a type of nuclear receptor and a modular steroid hormone receptor transcription factor. Specifically, the androgen receptor is activated by binding any of the androgenic hormones then translocating into the nucleus. Besides, the main function of the androgen receptor is to regulate gene expression...