BNS-22 is a DNA Topoisomerase II Catalytic Inhibitor
Topoisomerases (DNA topoisomerases) are enzymes that catalyze changes in the topological state of DNA, regulating the overwinding or underwinding of DNA. Topoisomerases play essential roles in DNA replication, transcription, chromosome segregation, and recombination. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. All...
Pirarubicin, an Anthracycline Antibiotics, Acts as a Topoisomerase II Inhibitor
Pirarubicin has widely application in intravesical chemotherapy for bladder cancer, but drug resistance limits its efficacy; the mechanism still needs further exploration. Bladder cancer is the most common malignancy of the urinary tract in China. 75–85% of bladder cancers are grouped as non-muscle invasive bladder tumors. Intravesical chemotherapy...