Romidepsin (FK 228) is an HDAC Inhibitor for Cancer Research
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more…
HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more…
Hsp90 (heat shock protein 90) is a chaperone protein that helps other proteins fold correctly, stabilizes proteins against heat stress, and aids in protein degradation. Besides, it stabilizes many proteins…
PAI-1 (plasminogen activator inhibitor-1, also known as SERPINE1) is a member of the serine protease inhibitor (SERPIN) family and is the primary inhibitor of two major mammalian plasminogen activators (urinary…
In this article, we introduce a specific inhibitor of transforming growth factor-β (TGF-β) -- PBrP. It suppresses TGF-β-induced cellular responsiveness by displacing type II TGF-β receptor (TβRII) from the plasma…
c-Myc is a member of the basic helix-loop-helix leucine zipper (bHLHZip) protein family. The target genes of the c-MYC protein participate in different cellular functions, including cell cycle, survival, protein…
Checkpoint kinase 1 (Chk1) is a conserved protein kinase that is critical to the Cell cycle checkpoint during DNA damage response (DDR). Specifically, CHK1 is the regulatory factor for G2/M…
PROTACs are bi-functional molecules, capable of concurrently binding to target proteins of interest and the subunits of E3 ligases, such as Cereblon, VHL, and MDM2, among others. In short, Cooperative…
Farnesyltransferase (farnesyltransferase, FTase) is composed of the α subunit encoded by the FNTA gene and the β subunit encoded by the FNTB gene. FTase recognizes the C-terminal CAAX motif of…
SRPIN803 can prevent VEGF production owing to the dual inhibition of SRPK1 and CK2. SRPKs are a critical enzyme family that regulates splicing activity in the cell. Serine-arginine protein kinase…
mTOR is the target of Rapamycin. In the early 1990s, genetic screens in budding yeast identified the TOR1 and TOR2 genes as mediators of the toxic effects of Rapamycin on…