PHPS1 is a Selective Shp2 Inhibitor
SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the human PTPN11 gene. Particularly, SHP2 contains a PTP catalytic domain and two SH2 domains. SHP2 is a ubiquitous PTP…
SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the human PTPN11 gene. Particularly, SHP2 contains a PTP catalytic domain and two SH2 domains. SHP2 is a ubiquitous PTP…
Signal transducer and activator of transcription 5 (STAT5) is a member of the STAT protein family. It is relevant to cell growth and differentiation. Specifically, STAT5 protein has related to…
Proteolytic targeting chimera (PROTAC) is a heterobifunctional small molecule that acts by inducing selective intracellular proteolysis. Specifically, bifunctional PROTAC molecule is including ligands of target protein (POI) and covalent ligands…
KIAA1718 is a histone demethylase for repressive methyl marks. what's more, KIAA1718 involves in transcriptional activation. Specifically, KIAA1718, as a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for histone…
PRMT5 is the main type II enzyme. It catalyzes symmetric dimethylarginine of histone proteins to induce gene silencing by generating repressive histone marks. PRMT5 can also methylate nonhistone proteins such…
The ubiquitin-proteasome system (UPS) plays an essential role in maintaining cellular homeostasis by degrading ubiquitinated proteins. The immunoproteasome and constitutive proteasome are multisubunit cylindrical complexes each containing three proteolytic subunits;…
Protein-protein interactions (PPIs) play a key role in nearly every biological function. And PPIs are a promising new class of biological targets for therapeutic intervention. In addition, PPIs governing the…
ADAMs (a disintegrin and metalloproteinases), originally also known as MDC proteins (metalloproteinase/disintegrin/cysteine-rich). And ADAMs belong to the Metzincins superfamily of metalloproteases. Recently, studies have found ADAM genes exist in animals,…
Histone acetyltransferases (HATs) are epigenetic enzymes that relieve transcriptional repression by preferentially acetylation of ε-amino group of lysine residues on histones. In general, HATs are crucial for chromatin restructuring and…
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease found in humans and other animals. Specifically, UPA is relevant to tissue remodeling and cell migration. The active…