PM-81I is a Potent STAT6 Inhibitor
The signal transducer and activator of transcription (STAT) belong to a group of latent cytoplasmic transcription factors that play a central role in transmitting signals from the cytoplasmic membrane to…
The signal transducer and activator of transcription (STAT) belong to a group of latent cytoplasmic transcription factors that play a central role in transmitting signals from the cytoplasmic membrane to…
BCR-ABL, a fusion gene, is a mutation that is formed by the combination of two genes, BCR and ABL. The BCR gene is normally on chromosome number 22. The ABL…
Acute myeloid leukemia (AML) is clinically and genetically heterogeneous hematopoietic cancer. Leukemia cells are unable to undergo growth arrest and terminal differentiation. The conventional chemotherapeutic approach for AML contains a…
HDACs (Histone deacetylases) are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly.…
Microtubules are polymers of tubulin, which is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the α-, β-, γ-, δ-,…
The transcription factor NF-κB is a nuclear factor that binds to the enhancer element of the immunoglobulin kappa light-chain of activated B cells. NF-κB exsists in nearly all cell types…
Kinesin, a member of microtubule-associated proteins, plays an important role in spindle assembly and chromosome movements during cell division. The kinesin motor protein family consists of 14 distinct subclasses and…
Chelerythrine is a natural benzophenanthridine alkaloid. It extracts from a number of plant species, such as Chelidonium majus, Macleaya cordata, Sanguinaria canadensis, etc. This compound exerts a wide spectrum of…
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations,…
To date, we identified 167 small GTPases in humans which are key signal transducing enzymes. Small GTPases comprise five main families whose eponymous members are Ras, Rho, Rab, ADP-ribosylation factor…