D6808 is a Highly Selective c‑Met Inhibitor used for NSCLC and Gastric Cancer Research
c-Met is a unique subfamily member of receptor tyrosine kinase (RTK) behaving as the receptor of hepatocyte growth factor (HGF)/scatter factor (SF). The HGF/c-Met signaling pathway plays important roles in a variety of biological activities. However, aberrant HGF/c-Met signaling is associated with the induction of a multitude of human...
Ficlatuzumab is a Human Hepatocyte Growth Factor (HGF) McAb
Hepatocyte growth factor (HGF) is an effective angiogenesis peptide. Specifically, it is produced by stromal cells and mesenchymal cells. It stimulates epithelial cell proliferation, movement, morphogenesis, and angiogenesis in various organs through tyrosine phosphorylation of its homologous receptor Met. Besides, HGF is located at 7q21 and has a length...
Tivantinib is a Selective c-Met Tyrosine Kinase Inhibitor
c-Met (hepatocyte growth factor receptor, HGFR) is a type of receptor tyrosine kinase which belongs to the MET family. c-Met exsists in the surfaces of various epithelial cells. Hepatocyte growth factor (HGF) is the ligand for c-Met. HGF belongs to the soluble cytokine family and is also a member...
XL092 is a Potent Axl, Mer and C-Met kinase Inhibitor
Human Axl belongs to the TAM subfamily of receptor tyrosine kinases that includes Mer. TAM kinases contain two immunoglobulin-like domains and two fibronectin type III domains. Many cancer cells exhibit overexpressed Axl. And it is initially cloned from patients with chronic myelogenous leukemia. Axl has been associated with cancers...
Crizotinib is an Orally Active, ATP-Competitive ALK and c-Met inhibitor
In this article, we will introduce an orally bioavailable, ATP-competitive ALK and c-Met inhibitor, Crizotinib. The IC50 values for ALK and c-Met kinases are 20 and 8 nM, respectively. Additionally, in cell-based assays, Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM, respectively. In...
Cabozantinib is a potent Multiple Receptor Tyrosine Kinases (RTKs) Inhibitor
Receptor tyrosine kinases (RTKs) are high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Specifically, RTKs are part of a larger family of protein tyrosine kinases. RTKs are key regulators of normal cellular processes. Besides, it plays a key role in the development and progression of...
Golvatinib (E-7050) is a potent Dual Inhibitor of both c-Met and VEGFR2 Kinases
c-Met is the cellular receptor for the hepatocyte growth factor (HGF). Activation of the HGF⁄c-Met pathway always leads to tumor progression, invasion, and metastasis. Vascular endothelial growth factor (VEGF) is an important molecule in tumor progression. Additionally, VEGF is associated with tumor angiogenesis. Due to their important role in...