Tag: c-Met

AMG-458 is a Selective and Orally Bioavailable c-Met Inhibitor

C-met is a protein encoded by a met gene in humans, which has tyrosine kinase activity. Specifically, Met is an essential one-way tyrosine kinase receptor for embryonic development, organogenesis, and wound healing. Besides, C-met is a receptor tyrosine kinase that can be activated by its ligand, hepatocyte growth factor/dispersion...

BPI-9016M is an Orally Active and Selective Dual c-Met/AXL Inhibitor

c-Met is a membrane-spanning receptor tyrosine kinase. It has a high affinity for binding to hepatocyte growth factor (HGF). As we all know, HGF/c-Met signaling often involves activation of its downstream pathways. High-level Met gene amplification, mutation or protein overexpression can lead to aberrant activation of the HGF/c-Met pathway. In...

BAY-474, a SGC Epigenetic Probe, is a Tyrosine-Protein Kinase c-Met Inhibitor

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. Genetic approaches are used to suppress the expression of the respective gene/protein. However, these methods have some deficiencies in drug discovery. They commonly remove or suppress the entire protein and they are...