Tag: Chemotherapy

ZLDI-8, an ADAM-17 and Notch Inhibitor, Enhances Chemotherapeutic Effects

ADAM metallopeptidase domain 17 (ADAM17) is an enzyme that belongs to the ADAM protein family of metalloproteases. ADAM17 plays a prominent role in the Notch signaling pathway. In this study, researchers demonstrated the discovery of ZLDI-8. ZLDI-8 is a novel inhibitor for Notch activating/cleaving enzyme ADAM-17. In particular, ZLDI-8...

JH-RE-06 is a Potent REV1-REV7 Interface Inhibitor for Chemotherapy Improvement

DNA-damaging chemotherapeutics, such as Cisplatin, have been the mainstay of cancer treatment for decades. These therapies generate DNA lesions, and high-fidelity replicative DNA polymerases as the template cannot utilization. Thus, it blocks the progression of the replication fork, generates cytotoxicity, and ultimately causes cell death. However, cells employ specialized...

CCT020312 is a Selective Activator of EIF2AK3/PERK

Genetic alterations that disable G1/S checkpoint control and loss of this checkpoint often happen in human cancer. The mechanisms contribute to cancer generation by permitting inappropriate proliferation and distorting fate-driven cell cycle exit. Therefore, the active compounds activate the G1/S checkpoint. And they may represent a broadly applicable and...