RAD51, an essential eukaryotic DNA recombinase, promotes homologous pairing and strand exchange during homologous recombination (HR) and the recombinational repair of double-strand breaks. RAD51 protein is recruited onto the DNA…
Poly (ADP-ribose) polymerase (PARP), a family of proteins, is involved in various cellular processes such as DNA repair and programmed cell death. PARP is present in the cell nucleus. It…
SET7 is a protein lysine methyltransferase (PKMT), which methylates a plethora of proteins and regulates diverse biological processes. Meanwhile, SET7 plays a significant role in transcriptional regulation, cell cycle control,…
Actinomycin D is isolated from Streptomyces species, containing a phenoxazine chromophore and two cyclic pentapeptide lactone rings. Besides, Actinomycin D can inhibit DNA repair, DNA-directed RNA synthesis, or DNA synthesis via…
DNA repair is very important for the maintenance of genome integrity in all organisms. Different exogenous agents or genotoxic products of metabolism cause multiple DNA repair systems evolved to eliminate…
Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes. PARP shares the ability to catalyze the transfer of ADP-ribose to target proteins. PARP plays an important role in various…
Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta. PCNA plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell…
DNA damage is an abnormal chemical structure in DNA, it undergoes DNA repair. DNA repair is a process to identify and correct DNA damage. If the process fails, irreparable DNA…
Non-Homologous End-Joining (NHEJ) is the important and crucial pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in solid tumors…