Tag: DNA Repair

D-I03 is a Selective RAD52 Inhibitor

DNA repair is very important for the maintenance of genome integrity in all organisms. Different exogenous agents or genotoxic products of metabolism cause multiple DNA repair systems evolved to eliminate a broad variety of DNA lesions. In normal cells, the specificities of different DNA repair mechanisms overlap to assure...

Niraparib is an Orally Active PARP Inhibitor

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes. PARP shares the ability to catalyze the transfer of ADP-ribose to target proteins. PARP plays an important role in various cellular processes, including modulation of chromatin structure, transcription, replication, recombination, and DNA repair. Niraparib (MK-4827) is a potent PARP...

ML367 is an ATAD5 Stabilization Inhibitor

DNA damage is an abnormal chemical structure in DNA, it undergoes DNA repair. DNA repair is a process to identify and correct DNA damage. If the process fails, irreparable DNA damage may happen. Consequently, this may lead to malignant tumors. ATAD5 (ATPase family AAA domain-containing protein 5) is a...

STL127705, an Inhibitor of the DNA Repair Protein Ku70/80

Non-Homologous End-Joining (NHEJ) is the important and crucial pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in solid tumors as a compensatory mechanism for a separate DSB repair defect or for innate genomic instability. Moreover, NHEJ also reduces...