Oltipraz is a Nrf2 Inhibitor
Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters involved in the efflux of a vast number of endogenous and exogenous chemicals. GSH is one of the liver's main defenses against oxidative…
Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters involved in the efflux of a vast number of endogenous and exogenous chemicals. GSH is one of the liver's main defenses against oxidative…
p53 acts as a tumor suppressor protein. Additionally, it plays s a pivotal role in several critical cellular processes, including cell-cycle regulation, DNA repair, and apoptosis. The p53 protein exerts…
The neurotransmitter 5-hydroxytryptamine (5-HT) has an array of pharmacological and physiological roles within the central nervous system. It has the potential to develop a number of useful medicines. The selective…
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histone and non-histone proteins. To date, 18 different mammalian HDACs have been identified and divided into four classes: the Class…
Protein kinases are enzymes that catalyze protein phosphorylation. Obviously, Protein kinases include many types of kinases, such as PKC,PKA, c-Fgr and phosphorylase kinase. Thereinto, PKC, PKA and phosphorylase kinase belong…
mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell…
Caspase is a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. They are named caspases due to their specific cysteine protease activity-a…
Cyclin-dependent kinase 7 (CDK7) is a catalytic subunit of CDK activated kinase (CAK). CAK is a kinase complex that catalyzes T-ring phosphorylation and activates a variety of cyclin-related kinases, including…
KIAA1718 is a histone demethylase for repressive methyl marks. what's more, KIAA1718 involves in transcriptional activation. Specifically, KIAA1718, as a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for histone…
Protein-protein interactions (PPIs) play a key role in nearly every biological function. And PPIs are a promising new class of biological targets for therapeutic intervention. In addition, PPIs governing the…