CD123, the alpha chain of the interleukin 3 receptor (IL-3Rα), is a molecule found on cells that helps transmit the signal for interleukin 3, a soluble cytokine important to the…
STING, stimulator of interferon gene, is an important protein in innate immunity. It can induce the production of type I interferon. STING performs an antiviral activity and innate immune response…
Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b for Large B-cell lymphomas (LBCL) Research. CD79b is a surface antigen whose expression is restricted to pre‐B and mature B cells. Besides,…
The pyrrolobenzodiazepines (PBD) are a class of compound that may have antibiotic or anti-tumor properties. They exert their biological activity by binding in the minor groove of DNA. PBD dimers…
BRD4 is a member of the BET family of proteins (BRD2, 3, 4, and T). It functions as an epigenetic “reader” of acetylated histone lysine residues via its two bromodomain…