Tag: ADC

CD123, the alpha chain of the interleukin 3 receptor (IL-3Rα), is a molecule found on cells that helps transmit the signal for interleukin 3, a soluble cytokine important to the immune system. Besides, Interleukin 3 (IL-3) is a soluble and pleiotropic cytokine. Additionally,  IL-3 regulates the function and production...

STING, stimulator of interferon gene, is an important protein in innate immunity. It can induce the production of type I interferon. STING performs an antiviral activity and innate immune response to inhibit intracellular pathogens. ADCs, antibody-drug conjugates, are popular targeted therapies tools for cancer. An ADC consists of a...

Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b for Large B-cell lymphomas (LBCL) Research.  CD79b is a surface antigen whose expression is restricted to pre‐B and mature B cells. Besides, CD79b is expressed on nearly all major subtypes of B-cell-derived NHL. While, Large B-cell lymphomas (LBCL) is a fast-growing...

The pyrrolobenzodiazepines (PBD) are a class of compound that may have antibiotic or anti-tumor properties. They exert their biological activity by binding in the minor groove of DNA. PBD dimers are a class of exquisitely potent DNA minor groove interstrand crosslinking agents. An important feature of the interstrand cross-links...

BRD4 is a member of the BET family of proteins (BRD2, 3, 4, and T). It functions as an epigenetic “reader” of acetylated histone lysine residues via its two bromodomain motifs (BD1 and BD2). Disruption of BRD4-histone interactions is an attractive strategy for the development of novel anti-cancer agents....