Tag: Microtubule

Rosabulin is a Potent Microtubule Inhibitor

Chemotherapy is a cornerstone in the development of present-day cancer therapy. Moreover, Chemotherapy is one of the most effective and potent strategies to treat malignant tumors. However, Chemotherapy resistance occurs when cancers that have been responding to therapy suddenly begin to grow. Rosabulin is a potent tubulin inhibitor. In...

PR-619 is a Broad-Range DUB Inhibitor

Ubiquitination is a post-translational modification where the polypeptide ubiquitin is attached to lysine residues of substrate proteins. This process is reversible, and ubiquitin removal is orchestrated by a large family of deubiquitinating enzymes (DUBs). DUBs fall into six subfamilies based on sequence and domain similarity. Ubiquitination and deubiquitination together...

AZ82 is a Selective Kinesin-Like Protein KIFC1 (HSET/KIFC1) Inhibitor

A study from Jiaquan Wu discovered and identified a KIFC1 inhibitor AZ82. Centrosome amplification occurs in many human cancers and has become a driver of both genetic instability and tumorigenesis. Cancer cells have evolved mechanisms to bundle multiple centrosomes into two spindle poles to avoid multipolar mitosis that can...

Cevipabulin (TTI-237) is a Microtubule-Active Antitumor Compound

Microtubules are part of the mitotic spindle, the complex and dynamic structure that mediates chromosome separation during mitosis. Therefore, microtubules are a proven target in cancer treatment. There have been many clinical drugs designed to target microtubule, including Paclitaxel and Vinblastine. Vincristine binds at one of three known pharmacologic...

SSE15206 is a Microtubule Polymerization Inhibitor

Microtubule, a highly dynamic structure, forms spindle fibers during mitosis. Several key cellular processes such as vesicular trafficking, intracellular signalling, cell motility and mitotic cell division depend on microtubules. In recent years, emerging studies have demonstrated the role of microtubule in targeted cancer therapy. For example, Paclitaxel, the most...