Tag: PKC

R59949 is a pan Diacylglycerol Kinase (DGK) Inhibitor

Diacylglycerol kinase (DGK) is a second messenger in its own right and can modulate the activity of PKC and several ion channels.  Chemokines are low MW extracellular signaling peptides secreted by tissue either constitutively during homeostasis or de novo during an inflammatory response. They are a diverse family of...

PS315, an Allosteric PKC Inhibitor Binding to the PIF-Pocket

Members of the protein kinase C (PKC) family are regulated by phosphorylation and by an N-terminal extension of the catalytic domain. In addition, AGC kinases are a group of protein kinases comprising PKA, protein kinase G, and PKC families. They typically have three conserved phosphorylation sites. Besides, all PKCs...

BJE6-106, a Selective PKCδ Inhibitor, Triggers Caspase-Dependent Apoptosis

Melanomas were responsible for more than 75% of estimated skin cancer deaths in 2012. And the incidence rate has been increasing for the last 30 years. Additionally, NRAS is the second most frequently mutated gene in melanoma. Researcheres also have demonstrated the sensitivity of cancer cell lines carrying KRAS...