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Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

Network of Cancer Research

Reliable, unbiased and up to date information in cancer research

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Breast Cancer Cancer

BPDA2 is a Highly Selective and Competitive SHP2 Inhibitor

Louis Gilman February 22, 2023

SH2-containing protein tyrosine phosphatase 2 (SHP2) is a carcinogenic phosphatase. Specifically, SHP2 participates in the downstream signal transmission of various RTK. So it is the shared signal node for analysis.…

Cancer

Toceranib is An Orally Active Inhibitor of Receptor Tyrosine Kinase (RTK)

Louis Gilman July 8, 2022

Toceranib is an orally active receptor tyrosine kinase (RTK) inhibitor. Besides, Toceranib inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. What’s more,…

Colorectal Cancer Kidney Cancer

Axitinib is a Multi-Targeted Tyrosine Kinase Inhibitor

Louis Gilman November 26, 2021

Vascular endothelial growth factor (VEGF) is an important signal protein. Importantly, it is involved in angiogenesis and angiogenesis (blood vessels grow from a pre-existing vascular system). All members of VEGF…

Breast Cancer Colorectal Cancer Hematological Malignancies Lung Cancer Non-Small Cell Lung Cancer Pancreas Cancer Small Cell Lung Cancer

Ganetespib (STA-9090) is a HSP90 Inhibitor

Louis Gilman October 14, 2021

Hsp90 is a molecular chaperone that regulates the posttranslational folding, stability, and function of its protein substrates (client proteins), many of which play critical roles in cell growth, differentiation, and…

Glioma

Cabozantinib is a potent Multiple Receptor Tyrosine Kinases (RTKs) Inhibitor

Louis Gilman September 12, 2021

Receptor tyrosine kinases (RTKs) are high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Specifically, RTKs are part of a larger family of protein tyrosine kinases. RTKs…

Pancreas Cancer

Sitravatinib (MGCD516) is an Orally Bioavailable RTK Inhibitor with PD-1 Blockade Activity

Louis Gilman June 3, 2021

Sarcomas are rare but highly aggressive mesenchymal tumors. Mutation and overexpression of many receptor tyrosine kinases (RTKs) including c-Met, PDGFR, c-Kit and IGF1-R drive defective signaling pathways in sarcomas. Sitravatinib…

Esophagus Cancer

IACS-13909 is a Selective and Orally Active SHP2 Inhibitor

Louis Gilman March 11, 2021

Src homology 2 domain-containing phosphatase (SHP2) is a phosphatase that mediates signaling downstream of multiple receptor tyrosine kinases. SHP2 suppresses signaling through the MAPK pathway. Furthermore, SHP2 inhibition has demonstrated…

Solid Tumors

TNO155 is an Orally Active WT SHP2 Inhibitor with Antineoplastic Activity

Louis Gilman May 23, 2020

SHP2 is a non-receptor ubiquitous protein tyrosine phosphatase and has a relatively conserved structure and function. The SHP2 includes the PTP domain, two SH2 domains, and a C-terminal tail containing…

Cancer

BAY-474, a SGC Epigenetic Probe, is a Tyrosine-Protein Kinase c-Met Inhibitor

Louis Gilman February 2, 2020

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. Genetic approaches are used to suppress the expression of the respective gene/protein. However,…

Melanoma Solid Tumors

Ravoxertinib is an Orally Active and Highly Selective ERK1/2 Inhibitor

Louis Gilman October 9, 2019

The RAS/RAF/MEK/ERK (MAPK) signal transduction pathway has attracted significant interest as a therapeutic target for cancer. ERK1/2 phosphorylates more than 50 downstream substrates responsible for cell growth, proliferation, survival, angiogenesis,…

Recent Posts

  • BI 7446 is a STING Agonist for Immuno-oncology Research
  • JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research
  • OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research
  • INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research
  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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