IDH889 is an Orally Available and Mutant Specific IDH1 Inhibitor
Heterozygous mutations in human cytoplasmic isocitrate dehydrogenase 1 (IDH1) at Arg132 (R132) occur in multiple cancer types, including acute myeloid leukemia, glioma, chondrosarcoma, and cholangiocarcinoma. In this study, Julian R.…