R59949 is a pan Diacylglycerol Kinase (DGK) Inhibitor
Diacylglycerol kinase (DGK) is a second messenger in its own right and can modulate the activity of PKC and several ion channels. Chemokines are low MW extracellular signaling peptides secreted…
Diacylglycerol kinase (DGK) is a second messenger in its own right and can modulate the activity of PKC and several ion channels. Chemokines are low MW extracellular signaling peptides secreted…
JAK2 and STAT3 have been extensively implicated in the development and progression of numerous cancers. STAT3 be also activated by EGFR, JAK2, and other TYKs activated by EGF, LIF, and…
Each of the ~1013 cells in the human body receives tens of thousands of DNA lesions per day. These lesions can block genome replication and transcription. If they are not…
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor (IR) kinase superfamily. It highly expresses in adult brain tissue and exerts an important role in…
Brominedomain can recognize acetylated lysine residues. As the "reader" of lysine acetylation, the bromine domain is responsible for the transduction of signals carried by acetylated lysine residues and transforming them…
The family of caveolin membrane proteins plays many roles in the cell’s structural, signaling, and transportation processes. Caveolin-1 (CAV) is a monotonic membrane protein, 22 kDa, it penetrates only one…
Apoptosis protein inhibitors (IAP) are a class of functional and structural proteins, which are endogenous inhibitors of apoptosis. Specifically, inappropriate mutation or regulation will usually lead to cancer or other…
Over the last decade, the FGFRs family has become an attractive validated therapeutic target notably in cancer. It consists of four members (FGFR1 to FGFR4) which are structurally related cell…
PARPs are implicated in a variety of cellular metabolic processes including DNA-damage repair and mitotic spindle formation. In particular, PARP1 is essential in repairing DNA single- and double-strand breaks. For…
Focal adhesion kinase (FAK) is a tyrosine kinase overexpressed in cancer cells. Especially, FAK plays an important role in the progression of tumors to a malignant phenotype. FAK associates with…